For Professionals

Are you a healthcare professional seeking minimally invasive pain treatment solutions to improve the quality of life of your patients or to understand how Pulsed RF can help relieve your patients pain? 

We can help you. We follow PRF developments closely and we will share the knowledge we have. Because we believe that knowledge will help your patients improve their quality of life. 

Pulsed Radiofrequency (PRF) is a technique developed in the late 1990s as a safer alternative to conventional continuous radiofrequency ablation. Unlike ablation, which produces thermal destruction of nervous tissue, PRF delivers short, high-frequency electrical pulses while maintaining tissue temperatures below the neurodestructive threshold. This allows modulation of neural activity without creating significant structural damage.

The mode of action is not yet fully understood, but evidence suggests that PRF influences both neuronal excitability and local immune responses. There are strong indications that PRF reduces oxidative stress which reduces inflammation.

PRF has been successfully applied in a wide range of pain conditions, including radicular pain, facet joint pain, sacroiliac pain and certain peripheral neuralgias. Clinical studies report meaningful pain relief with a favorable safety profile compared to destructive procedures. Importantly, patients often experience less post-procedural pain and shorter recovery times.

The treatment is performed using fluoroscopic or ultrasound guidance, with needles placed close to the target nerve or tissue. Energy is delivered in short bursts followed by silent phases that allow for heat dissipation. Parameters such as voltage and treatment duration are still being optimized, and ongoing research is working toward consensus on standardized protocols (like the Leiden Consensus).

Transcutaneous Pulsed Radiofrequency (TcPRF) is a non-invasive form of Pulsed Radiofrequency therapy in which brief bursts of electromagnetic energy are delivered through the skin via surface electrodes. Unlike invasive PRF, which requires a needle placed near a nerve, TcPRF acts externally — allowing safe, repeatable treatments without tissue penetration.

Mechanism of action

The primary mode of action of TcPRF is the reduction of oxidative stress in the treated area. By generating controlled electromagnetic fields, TcPRF influences cellular redox balance and restores the equilibrium between free radicals and antioxidant defenses. This normalization of the oxidative environment leads to a downregulation of inflammation, improved microcirculation and stabilization of neuronal membranes.

In practical terms, this results in:

• reduced inflammatory mediator activity
• normalization of nerve excitability
• restoration of cellular homeostasis 

Both forms of PRF — transcutaneous and invasive — share a common goal: to reduce pain by restoring balance in the body’s electrical and biochemical systems.

At Springlife, our focus is on TcPRF, the most patient-friendly way to bring these benefits to daily clinical care.

In recent years, transcutaneous PRF (TcPRF) has been developed, enabling non-invasive application through the skin. Early studies suggest promising results, particularly for inflammatory and musculoskeletal pain. This opens new opportunities for treating broader patient populations without procedural risk.

For physicians, PRF offers a tool that bridges the gap between conservative pain management and invasive surgical interventions. Its non-destructive nature makes it especially appealing for patients where nerve ablation carries significant risk. As evidence accumulates, PRF is becoming an increasingly important component of the interventional pain medicine toolbox.

If you wish to receive publications about PRF and TcPRF, please contact us (info@springlife.com)

Are you interested in PulsedRF and for example struggling with a case? Join our dedicated WhatsApp group, where professionals can easily connect, share experiences, and ask each other questions — both about using the Spring2 and about patient-related situations.

If you would like to be added to this group, please send an e-mail with your name, the clinic or hospital where you work and your cell phone number. Please note that your number will solely used to add you to the Spring Circle.

Springlife was founded on a legacy and a vision. My father pioneered Pulsed Radiofrequency (PRF) technology for the treatment of chronic pain, and since childhood I have seen how innovation in medicine can change lives. Today, chronic pain remains one of the greatest health challenges worldwide, and I believe the future lies in treatments that are minimally invasive, patient-friendly, and scientifically sound. With Springlife, I am determined to bring my father’s knowledge into the next generation of medical solutions. Our mission is ambitious yet simple: to make PRF part of the standard toolbox of every pain physician around the globe. We envision a world where pain is treated with precision, without unnecessary damage or invasive interventions. Where physicians are empowered with tools that work with the body, not against it. Springlife is more than a company — it is a mission to redefine how chronic pain is treated. And we are only at the beginning of this journey.