RedoxPRF

RedoxPRF refers to the concept that pulsed radiofrequency (PRF) exerts part of its therapeutic effect through modulation of cellular redox balance.

In many chronic pain conditions, an imbalance occurs between oxidative processes (driven by reactive oxygen species or ROS) and the body’s antioxidant defenses. This oxidative stress fuels inflammation, damages neural tissue and sensitizes pain pathways, perpetuating pain even after the original injury has healed.
PRF has been shown to restore this redox balance by reducing excess ROS and enhancing antioxidant responses. This process lowers inflammation, stabilizes nerve excitability and prevents maladaptive signaling from spreading within the nervous system. By targeting redox mechanisms, PRF acts at a cellular and molecular level, not just on nerve conduction.
RedoxPRF is therefore more than a neuromodulation technique — it represents a biological rebalancing therapy, interrupting the oxidative stress–inflammation–pain cycle. This emerging mechanistic insight strengthens the rationale for PRF’s use as a safe, non-destructive and repeatable treatment in interventional pain management.