Oxidative stress

Oxidative stress occurs when there is an imbalance between reactive oxygen species (ROS) — also known as free radicals — and the body’s antioxidant defenses.

In pain medicine, oxidative stress contributes to nerve injury, inflammation, and sensitization of pain pathways. It can damage cellular proteins, lipids, and DNA, amplifying both acute and chronic pain states. Conditions such as neuropathy, arthritis, and fibromyalgia are associated with increased oxidative stress.
Recent research shows that pulsed radiofrequency (PRF) helps restore this balance. By reducing oxidative stress at the cellular level, PRF lowers the production of inflammatory mediators, which in turn decreases pain sensitivity. This dual effect — reducing oxidative damage and calming inflammation — is thought to be one of the key mechanisms behind PRF’s success as a non-destructive pain treatment.