Neuropathic pain results from injury or dysfunction of the nervous system itself, rather than from direct tissue damage.
Patients often describe it as burning, tingling, electric shock–like or stabbing. Common causes include diabetes, shingles (post-herpetic neuralgia), nerve compression or spinal cord injury. Neuropathic pain can be resistant to standard analgesics, requiring treatments such as anticonvulsants, antidepressants, or interventional approaches like PRF. Because it is often chronic and disabling, neuropathic pain has a major impact on quality of life.