Ketamine

Ketamine is an anesthetic agent that, at lower doses, is used in pain management for its ability to modulate NMDA receptors in the nervous system.

It can reduce central sensitization and is sometimes applied in complex regional pain syndrome (CRPS) or severe neuropathic pain resistant to other treatments. Ketamine infusions are usually administered in specialized centers, with monitoring due to potential side effects like dissociation or hallucinations.